XIAP/cIAP1 antagonist-1
XIAP/cIAP1 antagonist-1 is a potent and orally active XIAP/cIAP1 antagonist with EC50s of 5.1 nM and 0.32 nM for XIAP and cIAP1, respectively. XIAP/cIAP1 antagonist-1 inhibits the tumor growth in dose-dependent manner in vivo[1].
Product Specifications
CAS Number
[1403898-55-4]
UNSPSC
12352005
Target
IAP
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xiap-ciap1-antagonist-1.html
Solubility
10 mM in DMSO
Smiles
C[C@H]1N(C[C@@H]2N(CC(N3CC(C)(C)C4=NC=C(CC5=CC=C(F)C=C5)C=C43)=O)C[C@@H](C)NC2)CCOC1
Molecular Formula
C29H40FN5O2
Molecular Weight
509.66
References & Citations
[1]Tamanini E, et al. Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP) . J Med Chem. 2017; 60 (11) :4611-4625.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CIAP-1; XIAP
Curated Selection
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