BET-IN-2
BET-IN-2 is a BET inhibitor with an IC50 of 52 nM for BRD4-BD1.
Product Specifications
CAS Number
2104688-91-5
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BET-IN-2.html
Solubility
10 mM in DMSO
Smiles
CC1=C([C@H](C)NC2=CC(N(C3CC3)[C@H](C)C(N4C)=O)=C4C=C2)C=CC(C)=C1
Molecular Formula
C23H29N3O
Molecular Weight
363.50
References & Citations
[1]Hu J, et al. Discovery of a series of dihydroquinoxalin-2 (1H) -ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor. Eur J Med Chem. 2017 Sep 8;137:176-195.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
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