Formycin A
Formycin A (NSC 102811), a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM. Formycin A shows antitumor and antiviral activities[1][2].
Product Specifications
CAS Number
6742-12-7
Product Name Alternative
NSC 102811
UNSPSC
12352005
Hazard Statement
H302
Target
Antibiotic; HIV; Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/formycin-a.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)C2=NNC3=C2N=CN=C3N
Molecular Formula
C10H13N5O4
Molecular Weight
267.24
Precautions
H302
References & Citations
[1]Dapp MJ , et al. Discovery of novel ribonucleoside analogs with activity against human immunodeficiency virus type 1.J Virol. 2014 Jan;88 (1) :354-63.|[2]Zhang M, et al. Comparative Investigation into Formycin A and Pyrazofurin A Biosynthesis Reveals Branch Pathways for the Construction of C-Nucleoside Scaffolds. Appl Environ Microbiol. 2020 Jan 7;86 (2) .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
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