Formycin A

Formycin A (NSC 102811), a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM. Formycin A shows antitumor and antiviral activities[1][2].

Product Specifications

CAS Number

[6742-12-7]

Product Name Alternative

NSC 102811

UNSPSC

12352005

Hazard Statement

H302

Target

Antibiotic; HIV; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/formycin-a.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)C2=NNC3=C2N=CN=C3N

Molecular Formula

C10H13N5O4

Molecular Weight

267.24

Precautions

H302

References & Citations

[1]Dapp MJ , et al. Discovery of novel ribonucleoside analogs with activity against human immunodeficiency virus type 1.J Virol. 2014 Jan;88 (1) :354-63.|[2]Zhang M, et al. Comparative Investigation into Formycin A and Pyrazofurin A Biosynthesis Reveals Branch Pathways for the Construction of C-Nucleoside Scaffolds. Appl Environ Microbiol. 2020 Jan 7;86 (2) .