Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Rucaparib (camsylate)

Rucaparib (AG014699) camsylate is an orally active, potent inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) with a Ki of 1.4 nM for PARP1. Rucaparib camsylate is a modest hexose-6-phosphate dehydrogenase (H6PD) inhibitor. Rucaparib camsylate has the potential for castration-resistant prostate cancer (CRPC) research[1][2][3][4].

Product Specifications

CAS Number

1327258-57-0

Product Name Alternative

AG014699 (camsylate) ; PF-01367338 (camsylate)

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rucaparib-camsylate.html

Solubility

10 mM in DMSO

Smiles

FC1=CC2=C3C(CCNC2=O)=C(C4=CC=C(CNC)C=C4)NC3=C1.O=S(C[C@@]5(C6(C)C)C(C[C@@]6([H])CC5)=O)(O)=O.[x]

Molecular Formula

C19H18FN3O.xC10H16O4S

References & Citations

[1]Thomas HD, et al. Preclinical selection of a novel poly (ADP-ribose) polymerase inhibitor for clinical trial. Mol Cancer Ther, 2007, 6 (3), 945-956.|[2]J Murray, et al. Tumour cell retention of rucaparib, sustained PARP inhibition and efficacy of weekly as well as daily schedules. Br J Cancer. 2014 Apr 15;110 (8) :1977-84.|[3]Matt Shirley, et al. Rucaparib: A Review in Ovarian Cancer. Target Oncol. 2019 Apr;14 (2) :237-246.|[4]Jianneng Li, et al. Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation. Sci Transl Med. 2021 May 26;13 (595) :eabe8226.|[5]Hunter JE, et al. NF-κB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699. Oncogene, 2012, 31 (2), 251-264.|[6]Daniel RA, et al. Inhibition of poly (ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma. Clin Cancer Res, 2009, 15 (4), 1241-1249.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

PARP1; PARP2; PARP3

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Human Necdin (NDN) ELISA Kit
RDR-NDN-Hu-01 96 Tests

Human Necdin (NDN) ELISA Kit

Sign In for Pricing
View Details
Human Necdin (NDN) ELISA Kit
RDR-NDN-Hu-02 48 Tests

Human Necdin (NDN) ELISA Kit

Sign In for Pricing
View Details
Frozen Tissue Sections, Ovary
CS620257 5x 5 µm

Frozen Tissue Sections, Ovary

Sign In for Pricing
View Details
Human ROR alpha (RORA) activation kit by CRISPRa
GA104130 1 Kit

Human ROR alpha (RORA) activation kit by CRISPRa

Sign In for Pricing
View Details
(1S,5R,6R)-5-Hydroxy-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic Acid Ethyl Ester
TRC-H940005-25MG 25 mg

(1S,5R,6R)-5-Hydroxy-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic Acid Ethyl Ester

Sign In for Pricing
View Details
Abl1 Mouse Gene Knockout Kit (CRISPR)
KN500669 1 Kit

Abl1 Mouse Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details