Tubulin polymerization-IN-24

Tubulin polymerization-IN-24 (compound HMBA) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-24 inhibits MCF-7 cells proliferation. Tubulin polymerization-IN-24 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-24 increase the GTP hydrolysis rate and inhibits microtubule assembly[1].

Product Specifications

CAS Number

[564468-51-5]

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-polymerization-in-24.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(C=CC=C2)/C(C3=CC=CC=C13)=C\C4=CC=C(OC)C(O)=C4

Molecular Formula

C22H16O3

Molecular Weight

328.36

References & Citations

[1]Chatterji BP, et al. HMBA depolymerizes microtubules, activates mitotic checkpoints and induces mitotic block in MCF-7 cells by binding at the colchicine site in tubulin. Biochem Pharmacol. 2010 Jul 1;80 (1) :50-61.