Prostaglandin D2-d9

Prostaglandin D2-d9 is the deuterium labeled Prostaglandin D2. Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].

Product Specifications

CAS Number

[2254642-52-7]

Product Name Alternative

PGD2-d9

UNSPSC

12352211

Target

Endogenous Metabolite; Prostaglandin Receptor

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Concentration

276.61 μM * 1 mL in Methyl acetate

Purity

99.0

Solubility

10 mM in DMSO|DMSO : 50mg/mL (ultrasonic; warming) |Ethanol : 75mg/mL (ultrasonic; warming)

Smiles

O[C@@H]1[C@@H]([C@H](C(C1)=O)/C=C/[C@H](CC([2H])(C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H])[2H])O)C/C=C\CCCC(O)=O

Molecular Formula

C20H23D9O5

Molecular Weight

361.52

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Suzuki F, et al. Transport of prostaglandin D2 into brain. Brain Res. 1986 Oct 22;385 (2) :321-8.|[3]Zhang BJ, et al. Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2 in mice. Acta Pharmacol Sin. 2017 Apr;38 (4) :469-476.|[4]Kida T, et al. Prostaglandin D2 Attenuates NSC 125066-Induced Lung Inflammation and Pulmonary Fibrosis. PLoS One. 2016 Dec 19;11 (12) :e0167729.