Prostaglandin D2-d4

Prostaglandin D2-d4 is the deuterium labeled Prostaglandin D2. Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].

Product Specifications

CAS Number

[211105-29-2]

Product Name Alternative

PGD2-d4

UNSPSC

12352211

Hazard Statement

H225, H319, H336

Target

Endogenous Metabolite; Prostaglandin Receptor

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Concentration

701.28 μM * 200 μL in Methyl acetate

Purity

98.8

Solubility

10 mM in DMSO

Smiles

CCCCC[C@H](O)/C=C/[C@@H]1[C@H]([C@@H](O)CC1=O)C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O

Molecular Formula

C20H28D4O5

Molecular Weight

356.49

Precautions

H225, H319, H336

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Suzuki F, et al. Transport of prostaglandin D2 into brain. Brain Res. 1986 Oct 22;385 (2) :321-8.|[3]Zhang BJ, et al. Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2 in mice. Acta Pharmacol Sin. 2017 Apr;38 (4) :469-476.|[4]Kida T, et al. Prostaglandin D2 Attenuates NSC 125066-Induced Lung Inflammation and Pulmonary Fibrosis. PLoS One. 2016 Dec 19;11 (12) :e0167729.