BIIE-0246 (dihydrochloride)
BIIE-0246 dihydrochloride (AR-H 053591 dihydrochloride) is a potent and highly selective non-peptide neuropeptide Y (NPY) Y2 receptor antagonist, with an IC50 value of 15 nM[1].
Product Specifications
CAS Number
246146-31-6
Product Name Alternative
AR-H 053591 (dihydrochloride)
UNSPSC
12352005
Target
Neuropeptide Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/biie-0246-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=CC=CC=C2C(N3CCN(CC3)C(CC4(CCCC4)CC(N[C@@H](CCCNC(N)=N)C(NCCN5C(N(C6=CC=CC=C6)N(C7=CC=CC=C7)C5=O)=O)=O)=O)=O)C8=CC=CC=C8N1.Cl.Cl
Molecular Formula
C49H59Cl2N11O6
Molecular Weight
968.97
References & Citations
[1]Dumont Y, et al. BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y (2) receptor antagonist. Br J Pharmacol. 2000 Mar;129 (6) :1075-88.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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