Uridine 5'-monophosphate-15N2, d11 (dilithium)

Uridine 5'-monophosphate-15N2, d11 (5'- Uridylic acid-15N2, d11) dilithium is deuterium and 15N labeled Uridine 5'-monophosphate (HY-101981) . Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea[1][2][3].

Product Specifications

Product Name Alternative

5'-Uridylic acid-15N2, d11 (dilithium)

UNSPSC

12352005

Target

Apoptosis; Cholinesterase (ChE) ; Endogenous Metabolite; Isotope-Labeled Compounds; Potassium Channel

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Solubility

10 mM in DMSO

Smiles

O=P(O[Li])(O[Li])OC([2H])([2H])[C@@]1([2H])O[C@]([15N](C([15N]2[2H])=O)C([2H])=C([2H])C2=O)([2H])[C@](O[2H])([2H])[C@]1([2H])O[2H]

Molecular Formula

C9D11Li2 15N2O9P

Molecular Weight

349.10

References & Citations

[1]Li G, et al. Uridine/UMP metabolism and their function on the gut in segregated early weaned piglets. Food Funct. 2019 Jul 17;10 (7) :4081-4089.|[2]Mehmet Cansev, et al. Oral uridine-5'-monophosphate (UMP) increases brain CDP-choline levels in gerbils. Brain Res. 2005 Oct 5;1058 (1-2) :101-8.|[3]Irina B Krylova, et al. The cardioprotective effect of uridine and uridine-5'-monophosphate: the role of the mitochondrial ATP-dependent potassium channel. Exp Gerontol. 2006 Jul;41 (7) :697-703.