(3aR) -Selitrectinib

(3aR) -Selitrectinib ((3aR) -LOXO-195) is an isform of Selitrectinib (HY-101977), which is a next-generation TRK kinase inhibitor, with IC50s of 0.6 nM and TRKA and TRKC, respectively[1].

Product Specifications

CAS Number

[1350884-56-8]

Product Name Alternative

(3aR) -LOXO-195

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Trk Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/3ar-selitrectinib.html

Solubility

10 mM in DMSO

Smiles

FC1=CN=C(CCC(N2)C)C([C@](CCC3)([H])N3C(C=CN4N=C5)=NC4=C5C2=O)=C1

Molecular Formula

C20H21FN6O

Molecular Weight

380.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Drilon A, et al. A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors. Cancer Discov. 2017 Sep;7 (9) :963-972.