HNMPA

HNMPA is a membrane impermeable insulin receptor tyrosine kinase inhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the human insulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities[1][2]

Product Specifications

CAS Number

132541-52-7

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Insulin Receptor

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/hnmpa.html

Solubility

10 mM in DMSO

Smiles

OC(P(O)(O)=O)C1=CC=C2C=CC=CC2=C1

Molecular Formula

C11H11O4P

Molecular Weight

238.18

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]K Baltensperger, et al. Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. Proc Natl Acad Sci U S A. 1992 Sep 1;89 (17) :7885-9.|[2]Peter Kovacs, et al. In vivo electrophysiological effects of insulin in the rat brain. Neuropeptides. 2009 Aug;43 (4) :283-93.