Tyrphostin 25
Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase with an IC50 value of 3 µM in A431 cells. Tyrphostin 25 is also a GPR35 agonist with an EC50 of 5.3 µM[1][2][3].
Product Specifications
CAS Number
118409-58-8
Product Name Alternative
AG82; Tyrphostin A 25; Tyrphostin AG 82; RG-50875
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
EGFR; GPR35
Type
Reference compound
Related Pathways
GPCR/G Protein; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tyrphostin-25.html
Purity
99.00
Solubility
DMSO : 30 mg/mL (ultrasonic; warming)
Smiles
N#C/C(C#N)=C/C1=CC(O)=C(O)C(O)=C1
Molecular Formula
C10H6N2O3
Molecular Weight
202.17
Precautions
H302, H312, H332
References & Citations
[1]Klemke RL, et al. Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J Cell Biol. 1994 Nov;127 (3) :859-66. |[2]Gazit A, et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989 Oct;32 (10) :2344-52.|[3]Deng H, et al. Tyrphostin analogs are GPR35 agonists. FEBS Lett. 2011 Jun 23;585 (12) :1957-62.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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