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Prostaglandin E2-d9

Prostaglandin E2-d9 is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation[1][2].

Product Specifications

CAS Number

[1356347-42-6]

Product Name Alternative

PGE2-d9; Dinoprostone-d9

UNSPSC

12352211

Hazard Statement

H302, H360

Target

Endogenous Metabolite; Isotope-Labeled Compounds; Prostaglandin Receptor

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Others

Field of Research

Cardiovascular Disease; Endocrinology

Concentration

1.38 mM * 100 μL in Methyl acetate

Purity

99.5

Solubility

10 mM in DMSO

Smiles

OC(CCC/C=C\C[C@@H]1[C@H]([C@@H](CC1=O)O)/C=C/[C@@H](O)CC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O

Molecular Formula

C20H23D9O5

Molecular Weight

361.52

Precautions

H302, H360

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Chouaib S, et al. The mechanisms of inhibition of human IL 2 production. II. PGE2 induction of suppressor T lymphocytes. J Immunol. 1984 Apr;132 (4) :1851-7.|[3]Fernandez-Repollet E, et al. In vivo effects of prostaglandin E2 and arachidonic acid on phagocytosis of fluorescent methacrylate microbeads by rat peritoneal macrophages. J Histochem Cytochem. 1982 May;30 (5) :466-70.|[4]Haylor J, et al. Renal vasodilator activity of prostaglandin E2 in the rat anaesthetized with pentobarbitone. Br J Pharmacol. 1982 May;76 (1) :131-7.

Shipping Conditions

Blue Ice

Storage Conditions

Solution, -20°C, 2 years

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-101952S1/Prostaglandin-E2-d9-SDS-MedChemExpress.pdf

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Isoform

EP

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