Prostaglandin E2-d4

Prostaglandin E2-d4 is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation[1][2].

Product Specifications

CAS Number

[34210-10-1]

Product Name Alternative

PGE2-d4; Dinoprostone-d4

UNSPSC

12352211

Hazard Statement

H302, H360

Target

Endogenous Metabolite; Prostaglandin Receptor

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease; Endocrinology

Concentration

1.40 mM * 100 μL in Methyl acetate

Purity

99.90

Solubility

10 mM in DMSO

Smiles

OC(CC([2H])([2H])C([2H])([2H])/C=C\C[C@@H](C(C1)=O)[C@H]([C@@H]1O)/C=C/[C@@H](O)CCCCC)=O

Molecular Formula

C20H28D4O5

Molecular Weight

356.49

Precautions

H302, H360

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Chouaib S, et al. The mechanisms of inhibition of human IL 2 production. II. PGE2 induction of suppressor T lymphocytes. J Immunol. 1984 Apr;132 (4) :1851-7.|[3]Fernandez-Repollet E, et al. In vivo effects of prostaglandin E2 and arachidonic acid on phagocytosis of fluorescent methacrylate microbeads by rat peritoneal macrophages. J Histochem Cytochem. 1982 May;30 (5) :466-70.|[4]Haylor J, et al. Renal vasodilator activity of prostaglandin E2 in the rat anaesthetized with pentobarbitone. Br J Pharmacol. 1982 May;76 (1) :131-7.