GNE-955
GNE-955 is a potent and orally active pan Pim kinase inhibitor with Kis of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively.
Product Specifications
CAS Number
1527523-39-2
UNSPSC
12352005
Hazard Statement
H315-H319
Target
Pim
Type
Reference compound
Related Pathways
JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GNE-955.html
Solubility
10 mM in DMSO
Smiles
CC1=CN=CC(C2=CC3=C(C=NN3C4=CC=C(OC)C(N5CCC[C@H](N)C5)=N4)C=N2)=N1
Molecular Formula
C22H24N8O
Molecular Weight
416.48
Precautions
P264-P280-P302+P352-P305+P351+P338-P362+P364
References & Citations
[1]Wang X, et al. Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability. J Med Chem. 2017 May 25;60 (10) :4458-4473.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PIM1; PIM2; PIM3
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