Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

9-Hydroxyellipticine (hydrochloride)

9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC50 values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively[1][2][3].

Product Specifications

CAS Number

52238-35-4

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/9-hydroxyellipticine-hydrochloride.html

Purity

99.0

Solubility

H2O : 3 mg/mL (ultrasonic; warming)

Smiles

OC1=CC2=C(NC3=C2C(C)=C(C=NC=C4)C4=C3C)C=C1.[H]Cl

Molecular Formula

C17H15ClN2O

Molecular Weight

298.77

Precautions

H302, H315, H319, H335

References & Citations

[1]Renault G, et al. In vivo exposure to four ellipticine derivatives with topoisomerase inhibitory activity results in chromosome clumping and sister chromatid exchange in murine bone marrow cells. Toxicol Appl Pharmacol. 1987 Jun 30;89 (2) :281-6.|[2]Saeki K, et al. Cardioprotective effects of 9-hydroxyellipticine on ischemia and reperfusion in isolated rat heart. Jpn J Pharmacol. 2002 May;89 (1) :21-8.|[3]G Renault, et al. In vivo exposure to four ellipticine derivatives with topoisomerase inhibitory activity results in chromosome clumping and sister chromatid exchange in murine bone marrow cells. Toxicol Appl Pharmacol. 1987 Jun 30;89 (2) :281-6.|[4]Ohashi M, et al. Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism. Jpn J Cancer Res. 1995 Sep;86 (9) :819-27.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Topo II

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

GABPA Protein Vector (Human) (pPM-C-His)
PV079832 500 ng

GABPA Protein Vector (Human) (pPM-C-His)

Sign In for Pricing
View Details
TK1 Antibody
32920-01 50 µL

TK1 Antibody

Sign In for Pricing
View Details
TK1 Antibody
32920-02 100 µL

TK1 Antibody

Sign In for Pricing
View Details
CD46P sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
K0402706 1.0 µg DNA

CD46P sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

Sign In for Pricing
View Details
CD31 (Platelet Endothelial Cell Adhesion Molecule, PECAM-1, EndoCAM, GPIIA', PECA1, PECAM1) (APC)
137711-APC 100 µL

CD31 (Platelet Endothelial Cell Adhesion Molecule, PECAM-1, EndoCAM, GPIIA', PECA1, PECAM1) (APC)

Sign In for Pricing
View Details
Lentiviral human ZSWIM3 sgRNA gene knockout kit - Lentiviral human ZSWIM3 sgRNA gene knockout kit (plasmid)
GTR15379847 1 Vial

Lentiviral human ZSWIM3 sgRNA gene knockout kit - Lentiviral human ZSWIM3 sgRNA gene knockout kit (plasmid)

Sign In for Pricing
View Details