(R)-SCH 42495
Product Specifications
UNSPSC Description
(R)-SCH 42495 is the less active enantiomer of SCH 42495[1]. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354[2].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Others; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/r-sch-42495.html
Solubility
10 mM in DMSO
Smiles
CSCC[C@@H](C(OCC)=O)NC([C@H](CSC(C)=O)CC1=CC=CC=C1C)=O
Molecular Weight
411.58
References & Citations
[1]Neustadt BR, et al. Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure-activity relationship studies of methionine and S-alkylcysteine derivatives. J Med Chem. 1994 Jul 22;37(15):2461-76.|[2]Watkins RW, et al. Atrial natriuretic factor potentiating and hemodynamic effects of SCH 42495, a new, neutral metalloendopeptidase inhibitor. Am J Hypertens. 1993 May;6(5 Pt 1):357-68.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101682B/R-SCH-42495-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101682B/
Clinical Information
No Development Reported
CAS Number
156792-25-5
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