(R) -SCH 42495

(R) -SCH 42495 is the less active enantiomer of SCH 42495[1]. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354[2].

Product Specifications

CAS Number

[156792-25-5]

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Field of Research

Others; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/r-sch-42495.html

Solubility

10 mM in DMSO

Smiles

CSCC[C@@H](C(OCC)=O)NC([C@H](CSC(C)=O)CC1=CC=CC=C1C)=O

Molecular Formula

C20H29NO4S2

Molecular Weight

411.58

References & Citations

[1]Neustadt BR, et al. Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure-activity relationship studies of methionine and S-alkylcysteine derivatives. J Med Chem. 1994 Jul 22;37 (15) :2461-76.|[2]Watkins RW, et al. Atrial natriuretic factor potentiating and hemodynamic effects of SCH 42495, a new, neutral metalloendopeptidase inhibitor. Am J Hypertens. 1993 May;6 (5 Pt 1) :357-68.