Deramciclane (fumarate)

Deramciclane fumarate is an antagonist of 5-HT Receptor. Deramciclane fumarate is an inverse agonist of 5-HT2C Receptor with an IC50 of 168 nM. Deramciclane fumarate also decreases basal phosphoinositide hydrolysis[1][2].

Product Specifications

CAS Number

[120444-72-6]

Product Name Alternative

EGIS-3886 (fumarate)

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/deramciclane-fumarate.html

Solubility

10 mM in DMSO

Smiles

CC1(C)[C@]2(C)[C@@](OCCN(C)C)(C3=CC=CC=C3)C[C@@]1([H])CC2.O=C(O)/C=C/C(O)=O

Molecular Formula

C24H35NO5

Molecular Weight

417.54

References & Citations

[1]Pälvimäki EP, et al. eramciclane, a putative anxiolytic drug, is a serotonin 5-HT2C receptor inverse agonist but fails to induce 5-HT2C receptor down-regulation. Psychopharmacology (Berl) . 1998 Mar;136 (2) :99-104.|[2]Kääriäinen TM, et al. Comparison of the effects of deramciclane, ritanserin and buspirone on extracellular dopamine and its metabolites in striatum and nucleus accumbens of freely moving rats. Basic Clin Pharmacol Toxicol. 2008 Jan;102 (1) :50-8.