5-HT6/7 antagonist 1
5-HT6/7 antagonist 1 is a multifunctional ligand that antagonizes 5-HT6/7/2A and D2 receptors, without interacting with M1 receptors and hERG channels.
Product Specifications
CAS Number
131999-28-5
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/1H-Isoindole-1,3_2H_-dione,_2-[2-[4-_6-fluoro-1,2-benzisoxazol-3-yl_-1-piperidinyl]ethyl]-.html
Solubility
10 mM in DMSO
Smiles
O=C1N(CCN2CCC(C3=NOC4=C3C=CC(F)=C4)CC2)C(C5=C1C=CC=C5)=O
Molecular Formula
C22H20FN3O3
Molecular Weight
393.41
References & Citations
[1]Kołaczkowski M, et al. Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia. J Med Chem. 2014 Jun 12;57 (11) :4543-57.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT6 Receptor; D2 Receptor; MUC2; MUC3; α-1 microglobulin
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