OPC-28326
OPC-28326 is a selective peripheral vasodilator and an angatonist of α2-adrenergic receptor, with Ki of 2040, 285, and 55 nM for α2A-, α2B- and α2C-adrenoceptors, respectively.
Product Specifications
CAS Number
[167626-17-7]
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/OPC-28326.html
Purity
99.46
Solubility
10 mM in DMSO
Smiles
CCC(NC1=C(C)C=C(C(N2CCC(N(C)CCC3=CC=CC=C3)CC2)=O)C=C1C)=O
Molecular Formula
C26H35N3O2
Molecular Weight
421.58
References & Citations
[1]Sumi M, et al. OPC-28326, a selective femoral arterial vasodilator, augments ischemia induced angiogenesis. Biomed Pharmacother. 2007 May;61 (4) :209-15. Epub 2006 Dec 28.|[2]Orito K, et al. alpha (2) -adrenoceptor antagonist properties of OPC-28326, a novel selective peripheral vasodilator. Br J Pharmacol. 2001 Oct;134 (4) :763-70.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
α adrenergic receptor
Curated Selection
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