10-Nitrooleate-d17 (nitrate)

10-Nitrooleate-d17 (nitrate) is the deuterium labeled 10-Nitrooleic acid nitrate. 10-Nitrooleic acid (CXA-10) nitrate, a nitro fatty acid, has potential effects in disease states in which oxidative stress, inflammation, fibrosis, and/or direct tissue toxicity play significant roles[1].

Product Specifications

CAS Number

[2749984-40-3]

UNSPSC

12352211

Hazard Statement

H225-H319

Target

Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Others

Field of Research

Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

[2H]C([2H])(/C([N+]([O-])=O)=C\CCCCCCCC(O)=O)C([2H])(C([2H])(C([2H])(C([2H])(C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H])[2H])[2H])[2H])[2H]

Molecular Formula

C18H16D17NO4

Molecular Weight

344.56

Precautions

P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P370+P378-P403+P235-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Garner RM, Mould DR, Chieffo C, Jorkasky DK. Pharmacokinetic and Pharmacodynamic Effects of Oral CXA-10, a Nitro Fatty Acid, After Single and Multiple Ascending Doses in Healthy and Obese Subjects. Clin Transl Sci. 2019;12 (6) :667-676. |[3]Zheng R, et al. Regulation of keratinocyte expression of stress proteins and antioxidants by the electrophilic nitrofatty acids 9- and 10-nitrooleic acid. Free Radic Biol Med. 2014;67:1-9.