Dot1L-IN-1
Dot1L-IN-1 is a highly potent and selective Dot1L inhibitor with a Ki of 2 pM and an IC50 of 50=3 nM), as well as the activity of the HoxA9 promoter (IC50=17 nM) in HeLa and Molm-13 cells, respectively[1].
Product Specifications
CAS Number
2088518-50-5
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Dot1L-IN-1.html
Solubility
10 mM in DMSO
Smiles
CC1=NC=CC=C1C2=C(Cl)SC3=CC=C(NC(NCC(NCCCN(C)[C@@H]4CCCN(C5=C(C=CN6)C6=NC=N5)C4)=O)=O)C=C32
Molecular Formula
C32H36ClN9O2S
Molecular Weight
646.21
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501
References & Citations
[1]Möbitz H, et al. Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach. ACS Med Chem Lett. 2017 Feb 14;8 (3) :338-343.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DOT1L
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS2514521-04 5x 96 Tests
Rabbit CFP (Complement Factor P) ELISA Kit
Sign In for Pricing
View Details MBS2514521-05 10x 96 Tests
Rabbit CFP (Complement Factor P) ELISA Kit
Sign In for Pricing
View Details