CYP17-IN-1
CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM[1].
Product Specifications
CAS Number
[2093317-51-0]
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cyp17-in-1.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=NC=C1CN(CC2)CC3=C2C4=CC(F)=CC=C4S3
Molecular Formula
C18H17FN2S
Molecular Weight
312.40
References & Citations
[1]Wang M, et al. Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors. Eur J Med Chem. 2017 May 26;132:157-172.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP17
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