CYP17-IN-1

CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM[1].

Product Specifications

CAS Number

[2093317-51-0]

UNSPSC

12352005

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cyp17-in-1.html

Solubility

10 mM in DMSO

Smiles

CC1=CC=NC=C1CN(CC2)CC3=C2C4=CC(F)=CC=C4S3

Molecular Formula

C18H17FN2S

Molecular Weight

312.40

References & Citations

[1]Wang M, et al. Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors. Eur J Med Chem. 2017 May 26;132:157-172.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CYP17

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