Deoxycytidine triphosphate-d14 (dilithium)

Deoxycytidine triphosphate-d14 (dCTP-d14 dilithium; 2′-Deoxycytidine-5′-triphosphate-d14) dilithium is deuterium labeled Deoxycytidine triphosphate (HY-101400) . Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.

Product Specifications

CAS Number

[2687960-70-7]

Product Name Alternative

DCTP-d14 (dilithium) ; 2′-Deoxycytidine-5′-triphosphate-d14 (dilithium)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog

Type

Isotope-Labeled Compounds

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Concentration

100 mM in 202.80 μL Tris HCl/D2O buffer pH=7.5

Purity

95.7

Solubility

10 mM in DMSO

Smiles

O=P(O[2H])(O[Li])OP(OP(OC([2H])([2H])[C@]1([2H])[C@](O[2H])([2H])C([2H])([2H])[C@@](N2C(N=C(N([2H])[2H])C([2H])=C2[2H])=O)([2H])O1)(O[2H])=O)(O[Li])=O

Molecular Formula

C9D14Li2N3O13P3

Molecular Weight

493.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]M H Tattersall, et al. Deoxyribonucleoside triphosphates in human cells: changes in disease and following exposure to drugs. Eur J Clin Invest. 1975 Apr;5 (2) :191-202.|[3]A W Harris, et al. Effect of thymidine on the sensitivity of cultured mouse tumor cells to 1-beta-D-arabinofuranosylcytosine. Cancer Res. 1979 Feb;39 (2 Pt 1) :538-41.|[4]B A Bladergroen, et al. CTP:phosphoethanolamine cytidylyltransferase. Biochim Biophys Acta. 1997 Sep 4;1348 (1-2) :91-9.