(+) -N-Allylnormetazocine (hydrochloride)

(+) -N-Allylnormetazocine ((+) -SKF 10047) hydrochloride is a benzomorphan opioid with psychotomi metic effects. (+) -N-Allylnormetazocine hydrochloride is an opioid receptor antagonist with Ki values of 300 nM and 27 μM for σ1 and σ2 opioid receptors, respectively. (+) -N-Allylnormetazocine hydrochloride can be used for the research of neurological disease[1][2].

Product Specifications

CAS Number

[133005-41-1]

Product Name Alternative

(+) -SKF 10047 (hydrochloride) ; (+) -N-Allyl-N-normetazocine (hydrochloride)

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/plus-n-allylnormetazocine-hydrochloride.html

Purity

99.6

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

C[C@@]1(CCN2CC=C)C3=CC(O)=CC=C3C[C@@]2([H])C1([H])C.Cl

Molecular Formula

C17H24ClNO

Molecular Weight

293.83

References & Citations

[1]May EL, et al. Synthesis and in vitro and in vivo activity of (-) - (1R,5R,9R) - and (+) - (1S,5S,9S) -N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2'-hydroxy-6,7-benzomorphan homologues. J Med Chem. 2000 Dec 28;43 (26) :5030-6.|[2]Brady KT, et al. Stereoisomers of N-allylnormetazocine: phencyclidine-like behavioral effects in squirrel monkeys and rats. Science. 1982 Jan 8;215 (4529) :178-80.