Chlorisondamine (diiodide)

Chlorisondamine (diiodide) is a potent nicotinic acetylcholine receptor (nAChR) antagonist and a ganglion blocker. Chlorisondamine antagonizes some of nicotine's central actions in a potent, long-lasting and pharmacologically selective way[1].

Product Specifications

CAS Number

[96750-66-2]

UNSPSC

12352005

Hazard Statement

H302, H410

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/chlorisondamine-diiodide.html

Purity

99.6

Solubility

DMSO : 10 mg/mL (ultrasonic; warming)

Smiles

C[N+](CC[N+]1(C)CC2=C(C(Cl)=C(Cl)C(Cl)=C2Cl)C1)(C)C.[I-].[I-]

Molecular Formula

C14H20Cl4I2N2

Molecular Weight

611.94

Precautions

H302, H410

References & Citations

[1]Clarke PB, et al. The pharmacology of the nicotinic antagonist, chlorisondamine, investigated in rat brain and autonomic ganglion. Br J Pharmacol. 1994 Feb;111 (2) :397-405. |[2]Clarke PB. Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion-blocking drug chlorisondamine. Br J Pharmacol. 1984;83 (2) :527-535. doi:10.1111/j.1476-5381.1984.tb16517.x|[3]Clarke PB. Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion-blocking drug chlorisondamine. Br J Pharmacol. 1984;83 (2) :527-535. doi:10.1111/j.1476-5381.1984.tb16517.x