MM 77 (dihydrochloride)

MM 77 dihydrochloride is a potent postsynaptic antagonist of the 5-HT1A receptor. MM 77 dihydrochloride exhibits anxiolytic-like activity[1][2].

Product Specifications

CAS Number

[159187-70-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mm-77-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(CC1)N(CCCCN2CCN(C3=CC=CC=C3OC)CC2)C1=O.Cl.Cl

Molecular Formula

C19H29Cl2N3O3

Molecular Weight

418.36

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Briones-Aranda Alfredo, et al. Effect of the postsynaptic 5-HT1A receptor antagonist MM-77 on stressed mice treated with 5-HT1A receptor agents. Eur J Pharmacol. 2005 Jan 31;508 (1-3) :155-8.|[2]Andrzej J Bojarski, et al. New imide 5-HT1A receptor ligands - modification of terminal fragment geometry. Molecules. 2004 Feb 28;9 (3) :170-7.