TRIM

TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC50 values of 28.2 and 27.0 μM, respectively. Antidepressant- and anxiolytic-like effects[1][2].

Product Specifications

CAS Number

[25371-96-4]

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/trim.html

Purity

99.90

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

FC(C1=CC=CC=C1N2C=CN=C2)(F)F

Molecular Formula

C10H7F3N2

Molecular Weight

212.17

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

References & Citations

[1]Handy RL, et al. The antinociceptive effect of 1- (2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br J Pharmacol. 1995;116 (5) :2349-2350. |[2]Volke V, et al. Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1- (2-trifluoromethylphenyl) -imidazole in mice. Behav Brain Res. 2003;140 (1-2) :141-147.