5-MCA-NAT

5-MCA-NAT is a melatonin agonist that may target the melatoninMT3 receptor. 5-MCA-NAT can contract the colonic band in a concentration-dependent manner and reduce intraocular pressure (IOP) in glaucomatous monkey eyes, inhibiting the increase in IOP[1][2].

Product Specifications

CAS Number

[190277-13-5]

UNSPSC

12352005

Target

Melatonin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/5-mca-nat.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC2=C(NC=C2CCNC(C)=O)C=C1)OC

Molecular Formula

C14H17N3O3

Molecular Weight

275.30

References & Citations

[1]Lucchelli A, et al. Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: the role of 5-HT4 and melatonin receptors. Br J Pharmacol. 1997 Aug;121 (8) :1775-81.|[2]Serle JB, et al. Effect of 5-MCA-NAT, a putative melatonin MT3 receptor agonist, on intraocular pressure in glaucomatous monkey eyes. J Glaucoma. 2004 Oct;13 (5) :385-8.