Glutaminyl Cyclase Inhibitor 3

Glutaminyl Cyclase Inhibitor 3 (compound 212), a designed anti-Alzheimer’s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor, with an IC50 of 4.5 nM. Glutaminyl Cyclase-IN-1 (compound 212) significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions[1].

Product Specifications

CAS Number

[2092921-50-9]

UNSPSC

12352005

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/glutaminyl-cyclase-inhibitor-3.html

Solubility

10 mM in DMSO

Smiles

COC1=C(OCCCCC2=CC(N)=NC=C2)C=CC(NC(NCCCN3C(C)=CN=C3)=S)=C1

Molecular Formula

C24H32N6O2S

Molecular Weight

468.61

References & Citations

[1]Hoang VH, et al. Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design. J Med Chem. 2017 Mar 23;60 (6) :2573-2590.