Glutaminyl Cyclase Inhibitor 3
Product Specifications
UNSPSC Description
Glutaminyl Cyclase Inhibitor 3 (compound 212 ), a designed anti-Alzheimer’s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor, with an IC50 of 4.5 nM. Glutaminyl Cyclase-IN-1 (compound 212) significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions[1].
Target Antigen
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/glutaminyl-cyclase-inhibitor-3.html
Solubility
10 mM in DMSO
Smiles
COC1=C(OCCCCC2=CC(N)=NC=C2)C=CC(NC(NCCCN3C(C)=CN=C3)=S)=C1
Molecular Weight
468.61
References & Citations
[1]Hoang VH, et al. Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design. J Med Chem. 2017 Mar 23;60(6):2573-2590.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101282/Glutaminyl-Cyclase-Inhibitor-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101282/
Clinical Information
No Development Reported
CAS Number
2092921-50-9
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
BNCB2883-500 500 µL
Anti-Topoisomerase I, Mitochondrial (TOP1MT) (TOP1MT/2883R), Biotin conjugate
Ask
View Details 