LB-60-OF61 (hydrochloride)
LB-60-OF61 hydrochloride is a potent NAMPT (nicotinamide phosphoribosyltransferase) inhibitor. LB-60-OF61 hydrochloride is a cytotoxic compound with a selectivity towards MYC overexpressing cell lines[1].
Product Specifications
CAS Number
[742064-38-6]
UNSPSC
12352005
Target
NAMPT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lb-60-of61-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC1=CC=CN=C1)C2=CC=C(OCC3=CC4=CN=C(C#N)N=C4N3CCC5CCCCC5)C=C2.[H]Cl
Molecular Formula
C29H31ClN6O2
Molecular Weight
531.05
References & Citations
[1]Estoppey D, et al. Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells. Sci Rep. 2017;7:42728. Published 2017 Feb 16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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