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LB-60-OF61 (hydrochloride)

LB-60-OF61 hydrochloride is a potent NAMPT (nicotinamide phosphoribosyltransferase) inhibitor. LB-60-OF61 hydrochloride is a cytotoxic compound with a selectivity towards MYC overexpressing cell lines[1].

Product Specifications

CAS Number

[742064-38-6]

UNSPSC

12352005

Target

NAMPT

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lb-60-of61-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(NCC1=CC=CN=C1)C2=CC=C(OCC3=CC4=CN=C(C#N)N=C4N3CCC5CCCCC5)C=C2.[H]Cl

Molecular Formula

C29H31ClN6O2

Molecular Weight

531.05

References & Citations

[1]Estoppey D, et al. Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells. Sci Rep. 2017;7:42728. Published 2017 Feb 16.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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