ICI 192605

ICI 192605 is a potent TXA2R (thromboxane A2 receptor) antagonist as cell signaling prostaglandin. ICI 192605 blocks contraction of isolated guinea pig trachea induced by U-46619[1].

Product Specifications

CAS Number

[117621-64-4]

UNSPSC

12352005

Hazard Statement

H302-H410

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/ici-192605.html

Solubility

10 mM in DMSO

Smiles

OC(CC/C=C\C[C@@H]1[C@H](C(C=CC=C2)=C2O)O[C@H](C(C=CC=C3)=C3Cl)OC1)=O

Molecular Formula

C22H23ClO5

Molecular Weight

402.87

Precautions

P264-P270-P273-P330-P391-P501

References & Citations

[1]Brewster AG, et al. The synthesis of a novel thromboxane receptor antagonist 4 (Z) -6- (2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl) hexenoic acid ICI 192605. Prostaglandins. 1988 Aug;36 (2) :173-8.