ICI 162846
ICI 162846 is an orally active antagonist of H2 receptor. ICI 162846 inhibits acid production accompanied by an increase in the secretion of histamine in chronic duodenal ulcer (CDU) models. ICI 162846 is effective in preventing CDU[1][2].
Product Specifications
CAS Number
84545-30-2
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ici-162846.html
Solubility
10 mM in DMSO
Smiles
O=C(N)CCCCN1N=C(NC(NCC(F)(F)F)=N)C=C1
Molecular Formula
C11H17F3N6O
Molecular Weight
306.29
References & Citations
[1]Wilson JA, et al. Inhibition of human gastric secretion by ICI 162,846--a new histamine H2-receptor antagonist. Br J Clin Pharmacol. 1986 Jun;21 (6) :685-9.|[2]Gompertz RH, et al. Acid blockade by omeprazole or ICI 162846 in a chronic duodenal ulcer model. Agents Actions. 1991 May;33 (1-2) :161-3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H2 Receptor
Available Sizes
Frequently Asked Questions
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