ICI 174864
ICI 174864 is a highly selective, potent δ-receptor antagonist. ICI 174864 is equipotent with naloxone and can not reverse the effect of the μ-agonist [D-Ala2, MePhe4, Gly-Ol5]enkephalin or the κ-agonist-tifluadom[1].
Product Specifications
CAS Number
[89352-67-0]
UNSPSC
12352209
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ici-174864.html
Purity
98.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C=CCN(CC=C)[C@H](C(NC(C)(C)C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CC1=CC=CC=C1)=O)=O)CC2=CC=C(C=C2)O
Molecular Formula
C34H46N4O6
Molecular Weight
606.75
References & Citations
[1]R Cotton, et, al. ICI 174864: a highly selective antagonist for the opioid delta-receptor. Eur J Pharmacol. 1984, 97,3.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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