(±) -threo-3-Methylglutamic acid

(±) -threo-3-Methylglutamic acid is a potent EAAT2/4 inhibitor. (±) -threo-3-Methylglutamic acid also is an ionotropic glutamate receptor agonist. (±) -threo-3-Methylglutamic acid inhibits glutamate uptake by rod outer segments[1][2].

Product Specifications

CAS Number

[63088-04-0]

UNSPSC

12352211

Hazard Statement

H315-H319-H335

Target

EAAT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/racemic-threo-3-methylglutamic-acid.html

Solubility

10 mM in DMSO

Smiles

OC([C@@H](N)[C@H](C)CC(O)=O)=O

Molecular Formula

C6H11NO4

Molecular Weight

161.16

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

References & Citations

[1]Eliasof S, et al. Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems. J Neurochem. 2001 Apr;77 (2) :550-7.|[2]Pignataro L, et al. Nonsynaptic localization of the excitatory amino acid transporter 4 in photoreceptors. Mol Cell Neurosci. 2005 Mar;28 (3) :440-51.