Asenapine (citrate)

Asenapine citrate, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0) . Asenapine citrate can be used in the research of schizophrenia and bipolar disorder[1][2].

Product Specifications

CAS Number

[1411867-74-7]

Product Name Alternative

Org 5222 (citrate)

UNSPSC

12352005

Target

5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/asenapine-citrate.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C2OC3=CC=CC=C3[C@@](C4)([H])[C@](CN4C)([H])C2=C1.O=C(CC(C(O)=O)(O)CC(O)=O)O

Molecular Formula

C23H24ClNO8

Molecular Weight

477.89

References & Citations

[1]M Shahid, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23 (1) :65-73.|[2]Olivia Frånberg, et al. Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia. Psychopharmacology (Berl) . 2008 Feb;196 (3) :417-29.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

D1 Receptor; D2 Receptor; D3 Receptor; D4 Receptor; H1 Receptor; H2 Receptor; mLAG-3; MUC2; MUC3; Prostaglandin D Synthase; α adrenergic receptor; α-1 microglobulin