THK-5117

THK-5117, an arylquinoline derivative, displays high binding affinity to tau fibrils with a Ki of 10.5 nM. THK-5117 has high binding affinity to tau protein aggregates and tau-rich Alzheimer disease (AD) brain homogenates. 18F-THK-5117 has the potential to act as a tau imaging PET probe[1].

Product Specifications

CAS Number

[1374107-54-6]

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/thk-5117.html

Purity

98.52

Solubility

10 mM in DMSO

Smiles

OC(COC1=CC=C2N=C(C3=CC=C(NC)C=C3)C=CC2=C1)CF

Molecular Formula

C19H19FN2O2

Molecular Weight

326.36

References & Citations

[1]Nobuyuki Okamura, et al. Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease. J Nucl Med. 2013 Aug;54 (8) :1420-7.