Sulfo-DGN462 (sodium)
Sulfo-DGN462 sodium is degraded to DGN462 in culture medium and plasma. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML) [1].
Product Specifications
CAS Number
1401203-09-5
UNSPSC
12352203
Target
ADC Payload; DNA Alkylator/Crosslinker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sulfo-dgn462-sodium.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(OC)=C2OCC3=CC(N(CC(C)(S)C)CCOCCOCCOC)=CC(COC(C=C(NC[C@@]4([H])N(C5=CC=CC=C5C4)C6=O)C6=C7)=C7OC)=C3)N(C8=CC=CC=C8C9)[C@]9([H])C(NC1=C2)[S](=O)(O[Na])=O
Molecular Formula
C53H60N5NaO12S2
Molecular Weight
1046.19
References & Citations
[1]Hicks SW, et al. The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models. Haematologica. 2019 Aug;104 (8) :1633-1639.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
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