(Rac)-BDA-366
Product Specifications
UNSPSC Description
(Rac)-BDA-366 (example 2) is the despinner of BDA-366 (HY-101083). BDA-366 is a potent Bcl-2 antagonist (Ki=3.3 nM), binding Bcl-2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl-2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells[1][2].
Target Antigen
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/rac-bda-366.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(NCC3OC3)C=CC(NCC(O)CN(CC)CC)=C2C(C4=CC=CC=C41)=O
Molecular Weight
423.50
References & Citations
[1]Spinx Pharmaceuticals Corp. Preparation of bis(hydroxyalkylamino) anthraquinones as protein kinase C inhibitors. World Intellectual Property Organization, WO9207557 A1 1992-05-14|[2]Han B, Park D, Li R, et al. Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy. Cancer Cell. 2015;27(6):852-863.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101083A/Rac-BDA-366-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101083A/
Clinical Information
No Development Reported
CAS Number
142645-19-0
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Human Monoclonal CD98 Antibody (Ign523) [Janelia Fluor 525]](https://cdn.genprice.uk/genprice/genprice4.png)
