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D-erythro-Sphingosine-d7

D-erythro-Sphingosine-d7 is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC) . D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

Product Specifications

CAS Number

1246304-34-6

Product Name Alternative

Erythrosphingosine-d7; erythro-C18-Sphingosine-d7; trans-4-Sphingenine-d7

UNSPSC

12352211

Target

Endogenous Metabolite; Phosphatase; PKC

Type

Isotope-Labeled Compounds

Related Pathways

Epigenetics; Metabolic Enzyme/Protease; TGF-beta/Smad

Field of Research

Cancer

Purity

99.00

Solubility

DMSO : 50 mg/mL (ultrasonic; warming)

Smiles

[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])CCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO

Molecular Formula

C18H30D7NO2

Molecular Weight

306.54

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Pushkareva MYu, et al. Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid basesand inhibition by non-esterified fatty acids. Biochem J. 1993 Sep 15;294 (Pt 3) :699-703.|[3]Khan WA, et al. Protein kinase C and platelet inhibition by D-erythro-Sphingosine: comparison with N, N-dimethylsphingosine and commercial preparation. Biochem Biophys Res Commun. 1990 Oct 30;172 (2) :683-91.|[4]Pham VT, et al. A concise synthesis of a promising protein kinase C inhibitor: D-erythro-Sphingosine. Arch Pharm Res. 2007 Jan;30 (1) :22-7.|[5]Cheng P, et al. Protein phosphatase 2A (PP2A) activation promotes axonal growth and recovery in the CNS. J Neurol Sci. 2015 Dec 15;359 (1-2) :48-56.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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