C-Met-IN-1
C-met-IN-1 (compound 16) is a potent and selective c-Met inhibitor, with IC50 of 1.1 nM, with antitumor activity.[1].
Product Specifications
CAS Number
[2084836-84-8]
UNSPSC
12352005
Target
C-Met/HGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c-met-in-1.html
Solubility
10 mM in DMSO
Smiles
FC1=CC(NC(C2=CN(C3=C(OC)C=CC=C3)C=N2)=O)=CC=C1OC4=CC=NC5=CC(OCCCN6CCN(C)CC6)=C(OC)C=C54
Molecular Formula
C35H37FN6O5
Molecular Weight
640.70
References & Citations
[1]Wang X, et al. Design, synthesis and biological evaluation of novel 4- (2-fluorophenoxy) quinoline derivatives as selective c-Met inhibitors. Bioorg Med Chem. 2017 Feb 1;25 (3) :886-896.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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