(2E) -OBAA
(2E) -OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC50 of 70 nM. (2E) -OBAA induces apoptosis of HUVEC cells. (2E) -OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei, with an IC50 of 0.4 μM[1][2][3][4].
Product Specifications
CAS Number
221632-26-4
UNSPSC
12352005
Target
Apoptosis; Phospholipase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/2e-obaa.html
Solubility
10 mM in DMSO
Smiles
O=C(O)/C=C/C(C1=CC=C(CCCCCCCCCCCCCCCCCC)C=C1)=O
Molecular Formula
C28H44O3
Molecular Weight
428.66
References & Citations
[1]J Y Miao, et al. Inhibitors of phospholipase promote apoptosis of human endothelial cells. J Biochem. 1997 Mar;121 (3) :612-8.|[2]J Eintracht, et al. Calcium entry in Trypanosoma brucei is regulated by phospholipase A2 and arachidonic acid. Biochem J. 1998 Dec 15;336 (Pt 3) (Pt 3) :659-66.|[3]T Köhler, et al. Phospholipase A2 inhibition by alkylbenzoylacrylic acids. Biochem Pharmacol. 1992 Aug 18;44 (4) :805-13.|[4]Kethineedi VR, et al. Quantum dot-NBD-liposome luminescent probes for monitoring phospholipase A2 activity. Anal Bioanal Chem. 2013 Dec;405 (30) :9729-37.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Phospholipase A
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