Naloxonazine (dihydrochloride)

Naloxonazine dihydrochloride is a specific μ-opioid receptor antagonist with an IC50 of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity[1][2][3].

Product Specifications

CAS Number

[880759-65-9]

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/naloxonazine-dihydrochloride.html

Purity

98.1

Solubility

H2O : ≥ 25 mg/mL

Smiles

O[C@@]([C@@]1([H])CC2=CC=C3O)(CC/4)[C@@]5(CCN1CC=C)C2=C3O[C@@]5([H])C4=N\N=C(CC[C@]67O)\[C@@]8([H])[C@]6(CCN(CC=C)[C@]7([H])CC9=CC=C%10O)C9=C%10O8.Cl.Cl

Molecular Formula

C38H44Cl2N4O6

Molecular Weight

723.69

References & Citations

[1]Chien CC, et al. Naloxonazine, a specific mu-opioid receptor antagonist, attenuates the increment of locomotor activity induced by acute methamphetamine in mice. Toxicol Lett. 2012 Jul 7;212 (1) :61-5.|[2]Hahn EF, et al. Naloxonazine, a potent, long-lasting inhibitor of opiate binding sites. Life Sci. 1982 Sep 20-27;31 (12-13) :1385-8.|[3]De Muylder G, et al. Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. PLoS Negl Trop Dis. 2016 Dec 30;10 (12) :e0005234.