Metaphit

Metaphit is a specific PCPantagonist and site-directed acylating agent of the [3H]phencyclidine binding site in rat brain homogenates[1]. Metaphit prevents PCP-induced locomotor behavior through presynaptic mechanisms[2].

Product Specifications

CAS Number

[96316-00-6]

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/metaphit.html

Solubility

10 mM in DMSO

Smiles

S=C=NC1=CC(C2(N3CCCCC3)CCCCC2)=CC=C1

Molecular Formula

C18H24N2S

Molecular Weight

300.46

References & Citations

[1]E D French, et al. Metaphit, a proposed phencyclidine (PCP) antagonist, prevents PCP-induced locomotor behavior through mechanisms unrelated to specific blockade of PCP receptors. Eur J Pharmacol. 1987 Aug 21;140 (3) :267-74|[2]M F Rafferty, et al. A specific acylating agent for the [3H]phencyclidine receptors in rat brain. FEBS Lett. 1985 Feb 25;181 (2) :318-22.