HA-100 (hydrochloride)

HA-100 hydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 hydrochloride also used as a ROCK inhibitor[1][2].

Product Specifications

CAS Number

[141543-63-7]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Myosin; PKA; PKC; ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ha-100-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCC3)=O.[H]Cl

Molecular Formula

C13H16ClN3O2S

Molecular Weight

313.80

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Hagiwara M, et, al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32 (1) :7-12.|[2]Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6 (3) :e17557.