HEAT (hydrochloride)
HEAT (BE2254) hydrochloride is a selective alpha 1 adrenergic receptor antagonist. HEAT hydrochloride, a phenethylamine derivative, shows pKis of 9, 9.1, and 8.57 for alpha 1a, alpha 1b and alpha 1c, respectively[1][2].
Product Specifications
CAS Number
30007-39-7
Product Name Alternative
BE2254 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/heat-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C1C(CNCCC2=CC=C(O)C=C2)CCC3=C1C=CC=C3.Cl
Molecular Formula
C19H22ClNO2
Molecular Weight
331.84
Precautions
P264-P270-P330-P501
References & Citations
[1]Chiu G, et al. Design and synthesis of an alpha1a-adrenergic receptor subtype-selective antagonist from BE2254. Chem Biol Drug Des. 2006;67 (6) :437-439.|[2]McPherson GA, et al. A study of alpha 1-adrenoceptors in rat renal cortex: comparison of [3H]-prazosin binding with the alpha 1-adrenoceptor modulating gluconeogenesis under physiological conditions. Br J Pharmacol. 1982;77 (1) :177-184.|[3]Tsujimoto G, et al. Alpha adrenergic receptors in the rabbit bladder base smooth muscle: alpha-1 adrenergic receptors mediate contractile responses. J Pharmacol Exp Ther. 1986;236 (2) :384-389.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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