HEAT (hydrochloride)

HEAT (BE2254) hydrochloride is a selective alpha 1 adrenergic receptor antagonist. HEAT hydrochloride, a phenethylamine derivative, shows pKis of 9, 9.1, and 8.57 for alpha 1a, alpha 1b and alpha 1c, respectively[1][2].

Product Specifications

CAS Number

[30007-39-7]

Product Name Alternative

BE2254 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/heat-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C1C(CNCCC2=CC=C(O)C=C2)CCC3=C1C=CC=C3.Cl

Molecular Formula

C19H22ClNO2

Molecular Weight

331.84

Precautions

P264-P270-P330-P501

References & Citations

[1]Chiu G, et al. Design and synthesis of an alpha1a-adrenergic receptor subtype-selective antagonist from BE2254. Chem Biol Drug Des. 2006;67 (6) :437-439.|[2]McPherson GA, et al. A study of alpha 1-adrenoceptors in rat renal cortex: comparison of [3H]-prazosin binding with the alpha 1-adrenoceptor modulating gluconeogenesis under physiological conditions. Br J Pharmacol. 1982;77 (1) :177-184.|[3]Tsujimoto G, et al. Alpha adrenergic receptors in the rabbit bladder base smooth muscle: alpha-1 adrenergic receptors mediate contractile responses. J Pharmacol Exp Ther. 1986;236 (2) :384-389.