Cis VH-298
Cis VH-298 is the cis form of VH-298. cis VH-298 results in a significant loss of binding specificity of hydroxylated HIF-1a peptides to VHL in vitro[1].
Product Specifications
CAS Number
2097381-86-5
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase; Ligands for E3 Ligase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Others
Assay Protocol
https://www.medchemexpress.com/cis-vh-298.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H]1N(C([C@H](C(C)(C)C)NC(C2(CC2)C#N)=O)=O)C[C@@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3
Molecular Formula
C27H33N5O4S
Molecular Weight
523.65
References & Citations
[1]Frost J, et al. Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nat Commun. 2016 Nov 4;7:13312.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
Frequently Asked Questions
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