Cis VH-298

Cis VH-298 is the cis form of VH-298 (HY-100947) . cis VH-298 results in a significant loss of binding specificity of hydroxylated HIF-1a peptides to VHL in vitro[1].

Product Specifications

CAS Number

[2097381-86-5]

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase; Ligands for E3 Ligase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Others

Assay Protocol

https://www.medchemexpress.com/cis-vh-298.html

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H]1N(C([C@H](C(C)(C)C)NC(C2(CC2)C#N)=O)=O)C[C@@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3

Molecular Formula

C27H33N5O4S

Molecular Weight

523.65

References & Citations

[1]Frost J, et al. Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nat Commun. 2016 Nov 4;7:13312.